Journal
TOXICOLOGY
Volume 291, Issue 1-3, Pages 122-132Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2011.11.005
Keywords
8:2 FTOH; Inhalation; Oral dose; Metabolism; Exposure; Risk assessment
Categories
Funding
- E.I. DuPont de Nemours and Company, Inc.
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8:2 fluorotelomer alcohol (8:2 FTOH) inhalation exposure was investigated to (1) compare plasma metabolites to oral data, (2) conduct a route-to-route extrapolation (oral to inhalation), (3) develop a human equivalent air concentration (HEC) from a 90-day oral sub-chronic study in rats using BMD analysis, and (4) calculate a margin of exposure (MOE) between the HEC and measured air concentrations. Male and female rats were exposed nose-only for 6 h at 3 or 30 mg/m(3). Blood was collected at 1,3 and 6 h during exposure and 6 and 18 h post exposure. Alcohol, perfluorocarboxylic acid and polyfluorinated acid metabolites were determined in plasma by LC-MS/MS. 8:2 FTOH was
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