Journal
TOXICOLOGY
Volume 259, Issue 1-2, Pages 10-17Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2009.01.010
Keywords
Wogonoside; Lipopolysaccharide; Angiogenesis; Toll-like receptor 4
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Funding
- National Natural Science Foundation of China [30701032, 90713038]
- International Technology Cooperation Programme [2008DFA32120]
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Wogonoside, one flavonoid derived from the root of Scutellaria baicalensis Georgi, has been reported for its anti-inflammation activity; however, whether it can inhibit inflammation-induced angiogenesis is still unclear. In the present study, we evaluated the effect of wogonoside on lipopolysaccharide (LPS)-induced angiogenesis in vitro and in vivo. Wogonoside suppressed the LPS-stimulated migration and tube formation of human umbilical vein endothelial cells (HUVECs), as well as microvessel sprouting from Fat aortic rings in vitro. Moreover, wogonoside also inhibited LPS-stimulated vessel growth of Chicken chorioallantoic membrane (CAM) in vivo. The mechanism revealed that wogonoside inhibited LPS-induced toll-like receptor 4 (TLR4) up-regulation and its downstream mitogen-activated protein kinases (MAPKs) activation, by decreasing the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase. The results suggest that wogonoside inhibits LPS-induced angiogenesis both in vitro and in vivo, and that it might have a therapeutic potential for the diseases associated with the development of both inflammation and angiogenesis progress. (C) 2009 Elsevier Ireland Ltd. All Fights reserved.
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