Journal
TOXICOLOGICAL SCIENCES
Volume 131, Issue 2, Pages 343-350Publisher
OXFORD UNIV PRESS
DOI: 10.1093/toxsci/kfs267
Keywords
developmental origins of health and disease; developmental toxicity; early-life exposure
Categories
Funding
- Society of Toxicology
- Agence Nationale de Securite Sanitaire Alimentation, environment, travail (ANSES)
- Alliance Nationale pour les Sciences de la Vie et de la Sante (Aviesan)
- Society of Toxicology Endowment Fund
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R13HD072606]
- European Environment Agency
- Forsythia
- International Society for Developmental Origins of Health and Disease (DOHaD)
- National Center for Toxicological Research (NCTR)
- National Institute of Environmental Health Sciences (NIEHS)
- National Institute for Environmental Studies (NIES)
- Sante Environnement Toxicologie Ile-de-France
- Superfund Research Program
- Universite Paris Descartes
- World Health Organization
- Oak Foundation
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Fetal and early postnatal development constitutes the most vulnerable time period of human life in regard to adverse effects of environmental hazards. Subtle effects during development can lead to functional deficits and increased disease risk later in life. The hypothesis stating that environmental exposures leads to altered programming and, thereby, to increased susceptibility to disease or dysfunction later in life has garnered much support from both experimental and epidemiological studies. Similar observations have been made on the long-term impact of nutritional unbalance during early development. In an effort to bridge the fields of nutritional and environmental developmental toxicity, the Society of Toxicology sponsored this work. This report summarizes novel findings in developmental toxicity as reported by select invited experts and meeting attendees. Recommendations for the application and improvement of current and future research efforts are also presented.
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