Journal
PLOS COMPUTATIONAL BIOLOGY
Volume 11, Issue 8, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.1004405
Keywords
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Funding
- CHDI Foundation, Inc. (chdifoundation.org operating grant)
- Canadian Institutes of Health Research (CIHR) [GPG-102165]
- National Institutes of Health (NIH) [P41 GM103533, R01 MH067880, R01 MH100175]
- UCLA/NHLBI Proteomics Centers [HHSN268201000035C]
- Fonds de Recherche du Quebec - Nature et Technologies
- Bluma Tischler postdoctoral fellowships
- CIHR Doctoral award
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P41GM103533] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH067880, R01MH100175] Funding Source: NIH RePORTER
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Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to multiple palmitoylation proteomics studies but these datasets are contained within large supplemental tables, making downstream analysis and data mining time-consuming and difficult. Consequently, we curated the data from 15 palmitoylation proteomics studies into one compendium containing 1,838 genes encoding palmitoylated proteins; representing approximately 10% of the genome. Enrichment analysis revealed highly significant enrichments for Gene Ontology biological processes, pathway maps, and process networks related to the nervous system. Strikingly, 41% of synaptic genes encode a palmitoylated protein in the compendium. The top disease associations included cancers and diseases and disorders of the nervous system, with Schizophrenia, HD, and pancreatic ductal carcinoma among the top five, suggesting that aberrant palmitoylation may play a pivotal role in the balance of cell death and survival. This compendium provides a much-needed resource for cell biologists and the palmitoylation field, providing new perspectives for cancer and neurodegeneration.
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