Journal
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Volume 233, Issue 2, Pages 135-140Publisher
TOHOKU UNIV MEDICAL PRESS
DOI: 10.1620/tjem.233.135
Keywords
exercise intensity; fibronectin type III domain-containing 5; irisin; myokine; peroxisome proliferator receptor gamma coactivator-1 alpha
Funding
- Grants-in-Aid for Scientific Research [26282180] Funding Source: KAKEN
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Irisin is mainly released from skeletal muscle (myocytes) and promotes thermogenesis by browning of the white adipose tissue. Although exercise has been shown to increase irisin concentration in blood and myocytes via up-regulation peroxisonne proliferator receptor gamma coactivator-1 alpha (PGC-1 alpha) expression, the influence of exercise intensity on irisin secretion remains unclear. Therefore, we determined circulating irisin responses following a single bout of running at different intensities. Six sedentary males underwent treadmill running under two different conditions: a low-intensity (40% of VO2max) exercise trial (LIE) or a high-intensity (80% of VO2max) exercise trial (HIE). The exercises in LIE and HIE were lasted for 20 and 40 min, respectively. All subjects underwent the two trials on separate days, and a randomized cross-over design was used. Blood samples were collected before (Pre) and immediately after exercise, at 3, 6, and 19 h after exercise. Energy consumption during exercise did not significantly differ between the two trials. HIE significantly increased blood lactate and serum lactate dehydrogenase levels (P < 0.05). Compared with pre-exercise levels, the irisin concentrations were elevated at 6 h (18% increase) and 19 h (23% increase) after HIE, but significantly decreased after LIE. The relative irisin concentrations (compared with pre-exercise levels) were significantly greater in HIE than in LIE immediately after exercise, and at 6 and 19 h after exercise (P < 0.05). These findings suggest that irisin secretion after acute running exercise is affected by exercise intensity, independent of energy consumption.
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