Journal
TISSUE ENGINEERING PART C-METHODS
Volume 18, Issue 6, Pages 464-474Publisher
MARY ANN LIEBERT INC
DOI: 10.1089/ten.tec.2011.0561
Keywords
-
Categories
Funding
- EU [LSHB-CT-2006-037409]
- University of Zurich
- Vontobel Foundation
- Werner Spross Foundation
Ask authors/readers for more resources
Tissue engineering of clinically applicable dermo-epidermal skin substitutes is crucially dependent on the three-dimensional extracellular matrix, supporting the biological function of epidermal and dermal cells. This matrix essentially determines the mechanical stability of these substitutes to allow for safe and convenient surgical handling. Collagen type I hydrogels yield excellent biological functionality, but their mechanical weakness and their tendency to contract and degrade does not allow producing clinically applicable transplants of larger sizes. We show here that plastically compressed collagen type I hydrogels can be produced in clinically relevant sizes (7 x 7 cm), and can be safely and conveniently handled by the surgeon. Most importantly, these dermo-epidermal skin substitutes mature into a near normal skin that can successfully reconstitute full-thickness skin defects in an animal model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available