Journal
TISSUE ENGINEERING PART B-REVIEWS
Volume 16, Issue 2, Pages 169-187Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.teb.2009.0352
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Categories
Funding
- NIH [R01 HL076485, R21 HL089913, P41-EB002520]
- NSERC
- CFI LOF
- NIH Graduate Fellowship [T 32 HL087745]
- Presidential Fellowship of Columbia University
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL087745, R21HL089913, R01HL076485] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [P41EB002520] Funding Source: NIH RePORTER
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Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelity models for studies of cardiac development and disease. In a general case, the biological potential of the cell-the actual tissue engineer''-is mobilized by providing highly controllable three-dimensional environments that can mediate cell differentiation and functional assembly. For cardiac regeneration, some of the key requirements that need to be met are the selection of a human cell source, establishment of cardiac tissue matrix, electromechanical cell coupling, robust and stable contractile function, and functional vascularization. We review here the potential and challenges of cardiac tissue engineering for developing therapies that could prevent or reverse heart failure.
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