Journal
TISSUE ENGINEERING PART B-REVIEWS
Volume 14, Issue 3, Pages 285-293Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.teb.2008.0084
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Funding
- Lyndon Peer Research Fellowship
- Plastic Surgery Educational Foundation (PSEF)
- American Society of Maxillofacial Surgery (ASMS)
- CMF
- PSEF Basic Science Research
- Alpha Omega Alpha (AOmegaA) Carolyn L. Kuckein Research Fellowship
- Association of Academic Plastic Surgeons (AAPS) Academic Scholar Award
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While it has been long appreciated that biomechanical forces are involved in bone remodeling and repair, the actual mechanism by which a physical force is translated to the corresponding intracellular signal has largely remained a mystery. To date, most biomechanical research has concentrated upon the effect on bone morphology and architecture, and. it is only recently that the complex cellular and molecular pathways involved in this process (called mechanotransduction) are being described. In this paper, we review the current understanding of bone mechanobiology and highlight the implications for clinical medicine and tissue engineering research.
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