Journal
TISSUE ENGINEERING PART A
Volume 15, Issue 6, Pages 1321-1329Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.tea.2008.0134
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Funding
- NINDS NIH HHS [F32 NS064771-01] Funding Source: Medline
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Synthetic substrates that mimic the properties of extracellular matrix proteins hold significant promise for use in systems designed for tissue engineering applications. In this report, we designed a synthetic polymeric substrate that is intended to mimic chemical, mechanical, and topological characteristics of collagen. We found that elastomeric poly(ester amide) substrates modified with replica-molded nanotopographic features enhanced initial attachment, spreading, and adhesion of primary rat hepatocytes. Further, hepatocytes cultured on nanotopographic substrates also demonstrated reduced albumin secretion and urea synthesis, which is indicative of strongly adherent hepatocytes. These results suggest that these engineered substrates can function as synthetic collagen analogs for in vitro cell culture.
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