Journal
TISSUE ENGINEERING PART A
Volume 15, Issue 10, Pages 3139-3149Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.tea.2008.0552
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Funding
- Ministero dell'Istruzione
- dell'Universita e della Ricerca Finanziamento Italiano della Ricerca di Base Idea Progettuale [RBIP06FH7J_002]
- Istituto Nazionale Biostrutture e Biosistemi (INBB)
- Italian Interuniversity Consortium on Materials Science and Technology
- INBB
- Materials Engineering Centre
- UdR INSTM
- NIPLAB
- University of Perugia
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The interaction between stem cells and biomaterials with nanoscale topography represents a main route in the roadmap for tissue engineering-based strategies. In this study, we explored the interface between human bone marrow-derived mesenchymal stem cells (hBM-MSCs) and hydrogenated amorphous carbon (a-C:H) film designed with uniform, groove, or grid nanopatterns. In either case, hBM-MSCs preserved growth rate and multi- differentiation properties, suggesting that the films were biocompatible and suitable for stem cell culture. hBM-MSCs responded to different nanopattern designs with specific changes of microtubule organization. In particular, the grid pattern induced a square-localized distribution of alpha-tubulin/actin fibers, whereas the groove pattern exerted a more dynamic effect, associated with microtubule alignment and elongation.
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