Journal
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume 11, Issue 2, Pages 106-112Publisher
KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
DOI: 10.1007/s13770-013-1114-9
Keywords
chitosan; alginate; scaffold; polyelectrolyte complex; osteogenic activity
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Funding
- Ministry for Health Welfare & Family Affairs, Republic of Korea [A091224]
- Regenerative Medicine RD
- Daegu Metropolitan City
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A chitosan (CS)/alginate (AG) hybrid scaffold was prepared through solid state polyelectrolyte complex (PEC) formation. The PEC formation was confirmed by Fourier-transformed infrared spectroscopy. Positive von Kossa staining of calcium depositions appeared in a large area of the CS/AG PEC scaffold cultured with osteoblastlike KUSA-A1 cells. The alkaline phosphatase activity of the cells cultured in the CS/AG scaffold was higher than that of the cells in the CS/hydroxyapatite (HA) scaffold. The osteogenic activity of the CS/AG PEC scaffold was considered comparable to that of the CS/HA scaffold. These findings suggest that modification of CS-based scaffold by PEC formation have a significant effect on the cell behavior towards osteogenic differentiation and bone tissue regeneration.
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