Journal
TISSUE ANTIGENS
Volume 82, Issue 1, Pages 43-47Publisher
WILEY-BLACKWELL
DOI: 10.1111/tan.12126
Keywords
HLA-B; HLA-C; major histocompatibility complex class I chain-related gene A; MICA-129; psoriasis; psoriatic arthritis
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Funding
- Krembil Foundation
- Canadian Institutes of Health Research (CIHR)
- University Health Network
- Abbott Psoriatic Arthritis Fellowship
- Canadian Arthritis Network
- MRC [U105261167, G0902100]
- British Heart Foundation [RG/08/014/24067] Funding Source: researchfish
- Medical Research Council [MC_U105261167, MR/L501566/1, MR/L003120/1, MC_EX_G0902100] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10165] Funding Source: researchfish
- MRC [MC_EX_G0902100, MC_U105261167, MR/L003120/1] Funding Source: UKRI
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A methionine/valine polymorphism at amino acid 129 of the major histocompatibility complex class I chain-related gene A (MICA-129) categorizes alleles into strong and weak binders of the natural killer (NK) and T-cell receptor NKG2D. We investigated whether MICA-129 is differentially associated with skin and joint manifestations of psoriatic disease (PsD) independently of human leukocyte antigen (HLA)-C and HLA-B in patients and controls from Toronto and St. John's. The MICA-129 methionine (Met) allele, particularly Met/Met homozygosity, was strongly associated with both cutaneous psoriasis (PsC) and psoriatic arthritis (PsA) independently of HLA-B and HLA-C in Toronto patients, and was also associated with PsA in St. John's patients, but with no additional effect of Met/Met homozygosity. No association remained after adjustment for HLA alleles in St. John's patients. MICA-129 was not associated with PsA when compared with PsC. We conclude that MICA-129 is a marker of skin manifestations of PsD that is independent of HLA class I in Toronto patients.
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