Journal
TISSUE ANTIGENS
Volume 76, Issue 5, Pages 404-410Publisher
WILEY
DOI: 10.1111/j.1399-0039.2010.01528.x
Keywords
allelic diversity; DRB; major histocompatibility complex; molecular evolution; Ursidae; Ursus arctos
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Funding
- [17405012]
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The allelic diversity of the DRB locus in major histocompatibility complex (MHC) genes was analyzed in the brown bear (Ursus arctos) from the Hokkaido Island of Japan, Siberia, and Kodiak of Alaska. Nineteen alleles of the DRB exon 2 were identified from a total of 38 individuals of U. arctos and were highly polymorphic. Comparisons of non-synonymous and synonymous substitutions in the antigen-binding sites of deduced amino acid sequences indicated evidence for balancing selection on the bear DRB locus. The phylogenetic analysis of the DRB alleles among three genera (Ursus, Tremarctos, and Ailuropoda) in the family Ursidae revealed that DRB allelic lineages were not separated according to species. This strongly shows trans-species persistence of DRB alleles within the Ursidae.
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