Journal
PAEDIATRICS AND INTERNATIONAL CHILD HEALTH
Volume 35, Issue 2, Pages 90-109Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/2046905515Y.0000000010
Keywords
Oedema; Albumin; Kwashiorkor; Nephrotic syndrome; Glycosaminoglycans; Glycocalyx; Proteoglycans; Vitamin E deficiency; Beriberi; Pre-eclampsia; War oedema; Famine oedema; Epidemic dropsy
Categories
Ask authors/readers for more resources
The various types of oedema in man are considered in relation to Starling's hypothesis of fluid movement from capillaries, with the main emphasis on nutritional oedema and the nephrotic syndrome in children. It is concluded that each condition has sufficient anomalous findings to render Starling's hypothesis untenable. The finding that the endothelial glycocalyx is key to control of fluid movement from and into the capillaries calls for complete revision of our understanding of oedema formation. The factors so far known to affect the function of the glycocalyx are reviewed. As these depend upon sulphated proteoglycans and other glycosaminoglycans, the argument is advanced that the same abnormalities will extend to the interstitial space and that kwashiorkor is fundamentally related to a defect in sulphur metabolism which can explain all the clinical features of the condition, including the formation of oedema.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available