Journal
TISSUE & CELL
Volume 40, Issue 6, Pages 459-466Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tice.2008.05.002
Keywords
Antimicrobials; Cathelicidin; Marsupials; hCAP18; LL37
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Funding
- Australian Research Council Discovery [DP0557854]
- Australian Research Council [DP0557854] Funding Source: Australian Research Council
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Antibodies to the human cathelicidin, hCAP18 have been used to examine epithelial tissues of adult and pouch Young marsupials. Immunoreactivity was observed in skin, gastrointestinal tract, lung and mammary node of adults as well as skin, gastrointestinal tract, lung and bone marrow Of Pouch Young. The locations of expression were similar to that reported in human tissues. Although the antibody to hCAP18 is primarily directed at the C-terminal antimicrobial peptide LL37, our observations suggest recognition of a common conserved element of this cathelicidin and lead LIS to conclude that the epithelial tissues of marsupials are sites of production of cathelicidin. This is consistent with observations in other mammals but is the first report of expression of these compounds in marsupials. (C) 2008 Elsevier Ltd. All rights reserved.
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