Journal
THROMBOSIS RESEARCH
Volume 125, Issue -, Pages S49-S51Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2010.01.037
Keywords
Microparticle; Exosome; Cancer
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Prokaryotic and eukaryotic cells release vesicles into their environment. To answer the question why eukaryotic cells release vesicles, we may learn from prokaryotes. Bacteria release outer membrane vesicles, resembling microparticles, which act as multi-purpose carriers. They contain signalling molecules for other bacteria, deliver toxins to host cells and exchange DNA encoding virulence genes between bacteria. Similarly, cell-derived microparticles and exosomes from eukaryotic cells are multi-purpose carriers containing e. g. signalling molecules, cellular waste and functional genetic information. To illustrate our rapidly increasing knowledge on the multiple roles that cellular microparticles and exosomes play in disease progression, we focus on cancer, which is one of the best studied diseases in this aspect. The clinical applications of microparticles and exosomes, including diagnosis, prognosis and therapy, in cancer are discussed. (C) 2010 Elsevier Ltd. All rights reserved.
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