Journal
THROMBOSIS RESEARCH
Volume 126, Issue 1, Pages 74-78Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2010.03.017
Keywords
DIC; Pre-DIC; Hemostatic markers; Mortality; Resolution rate
Categories
Funding
- Ministry of Health, Labour and Welfare, Japan for Blood Coagulation Abnormalities
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japanese Society of Thrombosis and Hemostasis, Japanese DIC Study Group
- Grants-in-Aid for Scientific Research [21249086, 21590614] Funding Source: KAKEN
Ask authors/readers for more resources
Disseminated intravascular coagulation (DIC) sometimes has a poor outcome, and therefore early diagnosis and treatment are required. This study prospectively evaluated the hemostatic abnormalities and the onset of DIC in 613 patients with underlying diseases to identify a useful marker for diagnosing Pre-DIC. Pre-DIC was defined as the condition of patients within a week before the onset of DIC. Initially, 34.4% of patients were diagnosed with DIC, and about 8.5% of the patients without DIC were diagnosed as DIC within a week after registration (pre-DIC). The mortality of DIC, Pre-DIC and without DIC was 35.3%, 32.4% and 17.2%, respectively. All hemostatic parameters were significantly worse in DIC than without DIC and the values of the prothrombin time ratio, platelet count and fibrin monomer complex could classify the three groups; DIC, pre-DIC and without DIC. No useful marker was identified that provided an adequate cutoff value to differentiate pre-DIC from without DIC. A multivariate analysis identified clinical symptoms that were related to poor outcome. DIC must be treated immediately; there is no specific marker to identify pre-DIC. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available