Journal
THROMBOSIS RESEARCH
Volume 125, Issue 3, Pages 205-209Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2009.11.004
Keywords
Platelets; Toll-like Receptors; Megakaryocytes; TLR2; TLR4
Categories
Funding
- NIH [P50HL083801, T32 HL07224]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007224, P50HL083801] Funding Source: NIH RePORTER
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Platelets have been extensively studied as hemostatic regulators, stopping uncontrolled flow of blood from an injured vessel and allowing for repair. However, multiple studies have shown that platelets can interact with bacterial proteins, particularly seen during sepsis and inflammation. Immune cells recognize pathogens through Toll-like Receptors (TLRs). These same receptors allow platelets to recognize bacterial proteins and regulate platelet immunity and function. This review examines the TLRs expressed on platelets and megakaryocytes and how these receptors affect the function of these cells. Through TLRs, platelets go beyond hemostatic regulation and play a pivotal role in inflammation and infection. (C) 2009 Elsevier Ltd. All rights reserved.
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