Journal
THROMBOSIS RESEARCH
Volume 125, Issue 2, Pages 112-118Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2009.06.033
Keywords
Tissue Factor; diabetes; cardiovascular complications
Categories
Funding
- NIH/NIDDK [KO1 DK65752]
- Norwegian Research Council
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Heightened activity of circulating Tissue Factor (TF) has been linked to a variety of macro-and microvascular cardiovascular complications commonly observed in diabetes mellitus. Systemic and localized vascular abnormalities comprise the most debilitating feature of diabetic pathophysiology. Blood monocytes are chronically activated in diabetes, and serve as the major source of bioactive intravascular TF. This review examines recent literature on this subject, with a special emphasis on the abnormal monocyte physiology in diabetes and the structural and functional diversity of circulating TF. (C) 2009 Elsevier Ltd. All rights reserved.
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