Journal
THROMBOSIS RESEARCH
Volume 125, Issue -, Pages S23-S25Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2010.01.027
Keywords
Membranes; Phospholipids; Tissue Factor; Factor VIIa; NMR
Categories
Funding
- NIH [HL47014, GM33775, GM75937, GM79530]
- American Heart Association [0920045G]
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Most steps of the blood clotting cascade require the assembly of a serine protease with its specific regulatory protein on a suitable phospholipid bilayer. Unfortunately, the molecular details of how blood clotting proteins bind to membrane surfaces remain poorly understood, owing to a dearth of techniques for studying protein-membrane interactions at high resolution. Our laboratories are tackling this question using a combination of approaches, including nanoscale membrane bilayers, solid-state NMR, and large-scale molecular dynamics simulations. These studies are now providing structural insights at atomic resolution into clotting protein-membrane interactions. (C) 2010 Elsevier Ltd. All rights reserved.
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