4.6 Article

Cytoprotective-selective activated protein C therapy for ischaemic stroke

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2014 Update A Report From the American Heart Association

Alan S. Go et al.

CIRCULATION (2014)

Article Cell Biology

Recent developments in biased agonism

James W. Wisler et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

Article Pharmacology & Pharmacy

Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

Patrick Lyden et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Article Clinical Neurology

Global stroke statistics

Amanda G. Thrift et al.

INTERNATIONAL JOURNAL OF STROKE (2014)

Review Clinical Neurology

Acute Ischemic Stroke Time, Penumbra, and Reperfusion

Nathan W. Manning et al.

STROKE (2014)

Article Hematology

Activated protein C based therapeutic strategies in chronic diseases

Fabian Bock et al.

THROMBOSIS AND HAEMOSTASIS (2014)

Article Clinical Neurology

Advances and Challenges in Treatment and Prevention of Ischemic Stroke

Aaron W. Grossman et al.

ANNALS OF NEUROLOGY (2013)

Article Cardiac & Cardiovascular Systems

Impact of Onset-to-Reperfusion Time on Stroke Mortality A Collaborative Pooled Analysis

Mikael Mazighi et al.

CIRCULATION (2013)

Review Hematology

Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway

E. A. M. Bouwens et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)

Article Clinical Neurology

Quality of life after TIA and stroke Ten-year results of the Oxford Vascular Study

Ramon Luengo-Fernandez et al.

NEUROLOGY (2013)

Article Clinical Neurology

Novel Approaches to Neuroprotection Trials in Acute Ischemic Stroke

Michael Tymianski

STROKE (2013)

Review Clinical Neurology

Review of Stroke Thrombolytics

Andrew Bivard et al.

JOURNAL OF STROKE (2013)

Review Pharmacology & Pharmacy

Molecular Mechanism of beta-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

Eric Reiter et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)

Article Pharmacology & Pharmacy

Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke

Patricia D. Williams et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

Article Neurosciences

Thrombin Activity Associated with Neuronal Damage during Acute Focal Ischemia

Bo Chen et al.

JOURNAL OF NEUROSCIENCE (2012)

Review Chemistry, Medicinal

Allosteric Modulation of Protease-Activated Receptor Signaling

I. Canto et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2012)

Article Medicine, General & Internal

Drotrecogin Alfa (Activated) in Adults with Septic Shock

V. Marco Ranieri et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Biochemistry & Molecular Biology

Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa-Induced Lung Injury in Mice

Nastasha Bir et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

Review Hematology

Multiple receptor-mediated functions of activated protein C

H. Weiler

HAMOSTASEOLOGIE (2011)

Article Biochemistry & Molecular Biology

Activated Protein C N-Linked Glycans Modulate Cytoprotective Signaling Function on Endothelial Cells

Fionnuala Ni Ainle et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds

Unice J. K. Soh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Hematology

The structure-function relationship of activated protein C Lessons from natural and engineered mutations

Karin C. A. A. Wildhagen et al.

THROMBOSIS AND HAEMOSTASIS (2011)

Review Neurosciences

Cytoprotective protein C pathways and implications for stroke and neurological disorders

Berislav V. Zlokovic et al.

TRENDS IN NEUROSCIENCES (2011)

Review Biochemistry & Molecular Biology

Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways

A. R. Rezaie

CURRENT MEDICINAL CHEMISTRY (2010)

Article Neurosciences

Blood-brain barrier permeability and tPA-mediated neurotoxicity

Rami Abu Fanne et al.

NEUROPHARMACOLOGY (2010)

Article Clinical Neurology

Thrombin Mediates Severe Neurovascular Injury During Ischemia

Bo Chen et al.

STROKE (2010)

Article Neurosciences

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

Huang Guo et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2009)

Article Endocrinology & Metabolism

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

Rashid Deane et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

Article Biochemistry & Molecular Biology

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity

Huang Guo et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Article Urology & Nephrology

Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury

Akanksha Gupta et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Hematology

The protein C pathway and pathologic processes

F. J. Castellino et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)

Review Biochemistry & Molecular Biology

Proteases Display Biased Agonism at Protease-Activated Receptors: Location Matters!

Angela Russo et al.

MOLECULAR INTERVENTIONS (2009)

Article Biochemistry & Molecular Biology

Dissociation of Activated Protein C Functions by Elimination of Protein S Cofactor Enhancement

Shona Harmon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

May H. Han et al.

NATURE (2008)

Article Immunology

Endotoxemia and sepsis mortality reduction by non-anticoagulant-activated protein C

Edward J. Kerschen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Biochemistry & Molecular Biology

Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1

Likui Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Hematology

The cytoprotective protein C pathway

Laurent O. Mosnier et al.

BLOOD (2007)

Article Multidisciplinary Sciences

Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization

Joseph N. McLaughlin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage

Tong Cheng et al.

NATURE MEDICINE (2006)

Article Biochemistry & Molecular Biology

Multifunctional specificity of the protein C/activated protein C Gla domain

Roger J. S. Preston et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Hematology

Inflammation and the activated protein C anticoagulant pathway

Charles T. Esmon

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2006)

Article Clinical Neurology

1,026 experimental treatments in acute stroke

VE O'Collins et al.

ANNALS OF NEUROLOGY (2006)

Article Clinical Neurology

Functional recovery after embolic stroke in rodents by activated protein C

BV Zlokovic et al.

ANNALS OF NEUROLOGY (2005)

Article Hematology

Protease-activated receptors in hemostasis, thrombosis and vascular biology

SR Coughlin

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)

Article Biochemistry & Molecular Biology

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C

D Liu et al.

NATURE MEDICINE (2004)

Article Hematology

Activated protein C:: Potential therapy for severe sepsis, thrombosis, and stroke

JH Griffin et al.

SEMINARS IN HEMATOLOGY (2002)

Article Medicine, General & Internal

Efficacy and safety of recombinant human activated protein C for severe sepsis.

GR Bernard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Article Medicine, Research & Experimental

Complete antithrombin deficiency in mice results in embryonic lethality

K Ishiguro et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)