Journal
THROMBOSIS AND HAEMOSTASIS
Volume 109, Issue 3, Pages 407-415Publisher
SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
DOI: 10.1160/TH12-09-0678
Keywords
Adhesion molecules; endothelial cells; endothelial barrier; permeability; capillaries
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Funding
- National Institutes of Health, NHLBI [RO1 HL74455-01]
- Ruth L. Kirschstein National Research Service Award [T32HL69766]
- American Heart Association Predoctoral Fellowship [AHA-11PRE7300043]
- Iris Cantor-UCLA Women's Health Center Executive Advisory Board
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Vascular permeability is a highly coordinated process that integrates vesicular trafficking, complex junctional rearrangements, and refined cytoskeletal dynamics. In response to the extracellular environment, these three cellular activities have been previously assumed to work in parallel to regulate the passage of solutes between the blood and tissues. New developments in the area of vascular permeability, however have highlighted the interdependence between trans- and para-cellular pathways, the cross-communication between adherens and tight junctions, and the instructional role of pericytes on endothelial expression of barrier-related genes. Additionally, significant effort has been placed in understanding the molecular underpinings that contribute to barrier restoration following acute permeability events and in clarifying the importance of context-dependent signaling initiated by permeability mediators. Finally, recent findings have uncovered an unpredicted role for transcription factors in the coordination of vascular permeability and clarified how junctional complexes can transmit signals to the nucleus to control barrier function. The goal of this review is to provide a concise and updated view of vascular permeability, discuss the most recent advances,in molecular and cellular regulation, and introduce integrated information on the central mechanisms involved in trang-endothelial transport.
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