Journal
THROMBOSIS AND HAEMOSTASIS
Volume 108, Issue 4, Pages 592-598Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH12-02-0097
Keywords
microRNA; biomarker; cardiovascular; diabetes
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Funding
- Diabetes Research UK [BDA 10/0004115]
- Juvenile Diabetes Research Foundation [17-2011-658]
- Department of Health via a National Institute for Health Research (NIHR) Biomedical Research Centre
- British Heart Foundation [SP/12/5/29574] Funding Source: researchfish
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MiRNAs are emerging as promising biomarkers in cardiovascular diseases and may constitute a novel mechanism of intercellular communication. Accurate quantification of circulating miRNAs is essential. A variety of technological approaches and platforms have been developed with increased sensitivity and specificity for the detection and quantification of circulating miRNAs. In this review, we focus on the technical aspects and discuss the analytical challenges in profiling circulating miRNAs.
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