Journal
THROMBOSIS AND HAEMOSTASIS
Volume 108, Issue 6, Pages 1089-1096Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH12-06-0396
Keywords
Angiotensin-(1-7); Angiotensin Converting Enzyme 2; Receptor Mas; thrombosis; platelet
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Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidity and mortality. Remarkable effort has been made to identify new drug targets. There is growing evidence indicating that the recently described counter-regulator axis of the renin-angiotensin system (RAS), composed of Angiotensin-Converting Enzyme 2 (ACE2), Angiotensin-(1-7) and the Mas receptor, has protective effects against thrombosis. In addition, it could be considered as a promising target for treating or preventing this disease. In this narrative review, we focused on the recent findings of the role of the ACE2/Angiotensin-(1-7)/Mas axis on the haemostatic process and its therapeutic potential.
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