Journal
THROMBOSIS AND HAEMOSTASIS
Volume 104, Issue 1, Pages 39-44Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH10-05-0269
Keywords
Human induced pluripotent stem cells; reprogramming; in vitro disease models; drug screening
Categories
Funding
- Hong Kong Research Grant Council (HKU) [8/CRF/09]
- NSFC/RGC [N_HKU 716/09]
- University of Hong Kong [200907176179]
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Recent advances in stem cell biology have transformed the understanding of cell physiology and developmental biology such that it can now play a more prominent role in the clinical application of stem cell and regenerative medicine. Success in the generation of human induced pluripotent stem cells (iPS) as well as related emerging technology on the iPS platform provide great promise in the development of regenerative medicine. Human iPS cells show almost identical properties to human embryonic stem cells (ESC) in pluripotency, but avoid many of their limitations of use. In addition, investigations into reprogramming of somatic cells to pluripotent stem cells facilitate a deeper understanding of human stem cell biology. The iPS cell technology has offered a unique platform for studying the pathogenesis of human disease, pharmacological and toxicological testing, and cell-based therapy. Nevertheless, significant challenges remain to be overcome before the promise of human iPS cell technology can be realised.
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