Journal
THROMBOSIS AND HAEMOSTASIS
Volume 104, Issue 5, Pages 886-893Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH10-01-0073
Keywords
C1 inhibitor; complement; kallikrein kinin system; sepsis; ischaemia reperfusion injury
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Funding
- National Institutes of Health [RO1-AI057366, R37-HD22082]
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C1 inhibitor (C1INH) is a serpin that regulates both complement and contact (kallikrein kinin) system activation It consists of a serpin do main that is highly homologous to other serpins and an amino terminal non serpin mum like domain Deficiency of C1INH results in hereditary angioedema a disease characterised by episodes of angioedema of the skin or the mucosa of the gastrointestinal tract or the oropharynx AI though early data suggested that angioedema was mediated via corn plement system activation the preponderance of the data indicate that bradykinin is the mediator In the past few years, it has become apparent that C1INH has additional anti inflammatory functions independent of protease inhibition These include interactions with leukocytes that may result in enhanced phagocytosis with endothelial cells via E and P selectins that interfere with leukocyte rolling and in turn results in suppression of transmigration of leukocytes across the endothelium and interactions with extracellular matrix components that may serve to concentrate C1INH at sites of inflammation In addition C1INH sup presses gram negative sepsis and endotoxin shock, partly via direct interaction with endotoxin that interferes with its interaction with macro phages thereby suppressing tumour necrosis factor a and other in flammatory mediators C1INH treatment improves outcome in a number of disease models including sepsis and other bacterial infections possibly malaria, ischaemia reperfusion injury (intestinal, he patic muscle cardiac, brain), hyper acute transplant rejection and other inflammatory disease models Recent data suggest that this effectiveness is the result of mechanisms that do not require protease inhibition in addition to both complement and contact system activation
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