Journal
THROMBOSIS AND HAEMOSTASIS
Volume 102, Issue 6, Pages 1071-1079Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH09-03-0186
Keywords
Rickettsia; Orientia tsutsugamushi; Ehrlichia ruminantium; endothelium; blood circulation
Categories
Funding
- NIH/NIAID [U54 AI057156, IR21AI069171]
- NIH [R01AI21242]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI069171, U54AI057156, R01AI021242] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The vascular endothelium is the main target of a limited number of infectious agents; Rickettsia, Ehrlichia ruminantium, and Orientia tsutsugamushi are among them. These arthropod-transmitted obligately-intracellular bacteria cause serious systemic diseases that are not infrequently lethal. In this review, we discuss the bacterial biology, vector biology, and clinical aspects of these conditions with particular emphasis on the interactions of these bacteria with the vascular endothelium and how it responds to intracellular infection. The study of these bacteria in relevant in vivo models is likely to offer new insights into the physiology of the endothelium that have not been revealed by other models.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available