Journal
THROMBOSIS AND HAEMOSTASIS
Volume 99, Issue 2, Pages 264-270Publisher
GEORG THIEME VERLAG KG
DOI: 10.1160/TH07-10-0638
Keywords
thrombosis; glycoprotein; von Willebrand factor; mutant; mice
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Funding
- NHLBI NIH HHS [R37 HL 41002, P01 HL 066105, R37 HL041002] Funding Source: Medline
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The von Willebrand factor (VWF) receptor complex, glycoprotein (GP)Ib-V-IX, and its main ligand VWF play a key role in the adhesion process of platelets to sites of vascular injury. Recent studies in mutant mice have shed new light on the importance of either molecule for the development of arterial and venous thrombosis. In this review, we summarize the most important aspects from these studies.
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