Journal
THORAX
Volume 69, Issue 1, Pages 90-92Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2013-203482
Keywords
-
Categories
Funding
- Academy of Medical Sciences (AMS) [AMS-SGCL8-Durrington] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/L000954/1] Funding Source: researchfish
- National Institute for Health Research [CL-2009-14-005] Funding Source: researchfish
- BBSRC [BB/L000954/1] Funding Source: UKRI
Ask authors/readers for more resources
It is characteristic of asthma that symptoms worsen overnight, particularly in the early hours of the morning. Nocturnal symptoms in asthma are common and are an important indicator for escalation of treatment. An extensive body of research has demonstrated that nocturnal symptoms of cough and dyspnea are accompanied by circadian variations in airway inflammation and physiologic variables, including airflow limitation and airways hyper-responsiveness. The molecular apparatus that underpins circadian variations, controlled by so called 'clock' genes, has recently been characterised. Clock genes control circadian rhythms both centrally, in the suprachiasmatic nucleus of the brain and peripherally, within every organ of the body. Here, we will discuss how clock genes regulate circadian rhythms. We will focus particularly on the peripheral lung clock and the peripheral immune clock and discuss how these might relate to both the pathogenesis and treatment of asthma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available