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CELL (2008)
Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects
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Ribosomal proteins are targets for the NEDD8 pathway
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EMBO REPORTS (2008)
Function and regulation of protein neddylation - 'Protein Modifications: Beyond the Usual Suspects' review series
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EMBO REPORTS (2008)
Disassembly of MDC1 Foci Is Controlled by Ubiquitin-Proteasome-dependent Degradation
Wei Shi et al.
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SCCRO (DCUN1D1) Is an Essential Component of the E3 Complex for Neddylation
Alexander Y. Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Ku80 removal from DNA through double strand break-induced ubiquitylation
Lisa Postow et al.
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A targeted proteomic analysis of the ubiquitin-like modifier Nedd8 and associated proteins
Jeffrey Jones et al.
JOURNAL OF PROTEOME RESEARCH (2008)
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation
Thimo Kurz et al.
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Single-strand break repair and genetic disease
Keith W. Caldecott
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ATR: an essential regulator of genome integrity
Karlene A. Cimprich et al.
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E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks
Latarsha J. Reid et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Ku recruits XLF to DNA double-strand breaks
Ken-ichi Yano et al.
EMBO REPORTS (2008)
Deubiquitination of FANCD2 is required for DNA crosslink repair
Vibe H. Oestergaard et al.
MOLECULAR CELL (2007)
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
Nadine K. Kolas et al.
SCIENCE (2007)
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
Michael S. Y. Huen et al.
CELL (2007)
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Niels Mailand et al.
CELL (2007)
Human CtIP promotes DNA end resection
Alessandro A. Sartori et al.
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RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
Grant S. Stewart et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
IgH class switching and translocations use a robust non-classical end-joining pathway
Catherine T. Yan et al.
NATURE (2007)
SUMO-targeted ubiquitin ligases in genome stability
John Prudden et al.
EMBO JOURNAL (2007)
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
Jennifer Lee et al.
MOLECULAR CELL (2007)
Substrate-mediated regulation of cullin neddylation
Eng-Hui Chew et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
Silvia Costantini et al.
DNA REPAIR (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Shuhei Matsuoka et al.
SCIENCE (2007)
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
Naoya Uematsu et al.
JOURNAL OF CELL BIOLOGY (2007)
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
Frank Stegmeier et al.
NATURE (2007)
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor
Patrick S. Tarpey et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
H. Christian Reinhardt et al.
CANCER CELL (2007)
Proteasome-independent functions of ubiquitin in endocytosis and signaling
Debdyuti Mukhopadhyay et al.
SCIENCE (2007)
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
Pierre-Olivier Mari et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
Minli Wang et al.
NUCLEIC ACIDS RESEARCH (2006)
Ubiquitin-binding domains
James H. Hurley et al.
BIOCHEMICAL JOURNAL (2006)
A ubiquitin ligase complex assembles linear polyubiquitin chains
Takayoshi Kirisako et al.
EMBO JOURNAL (2006)
RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40
Laura J. Simpson et al.
EMBO REPORTS (2006)
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation
Yuichi J. Machida et al.
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A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
Dong Zhang et al.
CELL (2006)
Destruction of claspin by SCFβTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
Niels Mailand et al.
MOLECULAR CELL (2006)
SCFβTrCP-mediated degradation of claspin regulates recovery from the DNA replication checkpoint response
Angelo Peschiaroli et al.
MOLECULAR CELL (2006)
An ATR- and BRCA1-mediated fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication
Wenge Zhu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage
Hengbin Wang et al.
MOLECULAR CELL (2006)
The multifaceted mismatch-repair system
J Jiricny
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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
S Bekker-Jensen et al.
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Differential recruitment of DNA ligase I and III to DNA repair sites
Oliver Mortusewicz et al.
NUCLEIC ACIDS RESEARCH (2006)
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A Jazayeri et al.
NATURE CELL BIOLOGY (2006)
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
M Stucki et al.
CELL (2005)
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
M Bienko et al.
SCIENCE (2005)
Disruption of mechanisms that prevent rereplication triggers a DNA damage response
V Archambault et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C-elegans and S-cerevisiae
T Kurz et al.
NATURE (2005)
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex
K Sugasawa et al.
CELL (2005)
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
JH Lee et al.
SCIENCE (2005)
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
HE Bryant et al.
NATURE (2005)
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H Farmer et al.
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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
J Falck et al.
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Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1
DT Huang et al.
MOLECULAR CELL (2005)
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway
SMB Nijman et al.
MOLECULAR CELL (2005)
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation
IA Manke et al.
MOLECULAR CELL (2005)
Function and regulation of Cullin-RING ubiquitin ligases
MD Petroski et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
T Stiff et al.
CANCER RESEARCH (2004)
Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination
K Watanabe et al.
EMBO JOURNAL (2004)
The role of the DNA double-strand break response network in meiosis
C Richardson et al.
DNA REPAIR (2004)
An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
M O'Driscoll et al.
DNA REPAIR (2004)
The cellular response to general and programmed DNA double strand breaks
CH Bassing et al.
DNA REPAIR (2004)
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
DP Xirodimas et al.
CELL (2004)
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Y Huyen et al.
NATURE (2004)
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
A Sancar et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2004)
Interaction of human DNA polymerase η with monoubiquitinated PCNA:: A possible mechanism for the polymerase switch in response to DNA damage
PL Kannouche et al.
MOLECULAR CELL (2004)
Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7
D Koinuma et al.
EMBO JOURNAL (2003)
Requirement of the MRN complex for ATM activation by DNA damage
T Uziel et al.
EMBO JOURNAL (2003)
The Prp19p-associated complex in spliceosome activation
SP Chan et al.
SCIENCE (2003)
A novel ubiquitin ligase is deficient in Fanconi anemia
AR Meetei et al.
NATURE GENETICS (2003)
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage
SF El-Khamisy et al.
NUCLEIC ACIDS RESEARCH (2003)
Conservation in the mechanism of nedd8 activation by the human AppBp1-Uba3 heterodimer
RN Bohnsack et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins
HM Mendoza et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
L Zou et al.
SCIENCE (2003)
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage
R Groisman et al.
CELL (2003)
Chk1 and Chk2 kinases in checkpoint control and cancer
J Bartek et al.
CANCER CELL (2003)
Fission yeast COP9/signalosome suppresses cullin acivity through recruitment of the deubiquitylating enzyme Ubp12p
CS Zhou et al.
MOLECULAR CELL (2003)
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
M O'Driscoll et al.
NATURE GENETICS (2003)
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
V Costanzo et al.
MOLECULAR CELL (2003)
The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1
H Walden et al.
MOLECULAR CELL (2003)
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
JY Zheng et al.
MOLECULAR CELL (2002)
NEDD8 modification of CUL1 short article dissociates p120CAND1, an inhibitor of CULl-SKP1 binding and SCIF ligases
JD Liu et al.
MOLECULAR CELL (2002)
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1
GA Cope et al.
SCIENCE (2002)
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
H Takai et al.
EMBO JOURNAL (2002)
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
C Hoege et al.
NATURE (2002)
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
A Hirao et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein
J Tang et al.
DNA REPAIR (2002)
Defining interactions between DNA-PK and ligase IV/XRCC4
HL Hsu et al.
DNA REPAIR (2002)
U box proteins as a new family of ubiquitin-protein ligases
S Hatakeyama et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
JR Walker et al.
NATURE (2001)
DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways
M de Jager et al.
NUCLEIC ACIDS RESEARCH (2001)
Ku entry into DNA inhibits inward DNA transactions in vitro
P Frit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis
M Molinari et al.
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