Journal
THIN SOLID FILMS
Volume 517, Issue 5, Pages 1794-1798Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.tsf.2008.09.080
Keywords
Porous polymer films; Drug delivery; Rhodamine B; Ultrasound; Pulsatile release
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Funding
- National Science Foundation
- Pennsylvania State University
- National Nanotechnology Infrastructure Network
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A nanoporous polymer thin film has been developed as a potential platform for drug delivery. The film was fabricated by a light-induced polymerization process in which non-reactive solvent was first separated from photopolymer (dipentaerythritol penta-/hexa-acrylate as the monomer) and then removed from polymer via evaporation, yielding pores with diameters between 20 and 40 nm. Loading and release of Rhodamine B (drug model molecules) on both porous and non-porous thin films proved that nanopores enhanced the film's effectiveness in encapsulating and releasing the drug model molecules. which was attributed to the high surface-to-volume ratio of nanoporous film. Ultrasound-enhanced cumulative and pulsatile release revealed the advantages of ultrasound in controlled drug delivery. (C) 2008 Elsevier B.V. All rights reserved.
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