Journal
SCIENTIFIC WORLD JOURNAL
Volume -, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2014/471463
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Funding
- National Natural Science Foundation of China [81272143, 21203131]
- Natural Science Foundation of Jiangsu Province [K200509]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [12KJB180014]
- Jiangsu Innovation Team Grant [LJ201141]
- Program of Innovative and Entrepreneurial Talent
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Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-alpha (TNF-alpha) test in NS. Our collectible studies were searched from PUBMED, EMBASE, and the Cochrane Library between March 1994 and August 2013. Accordingly, 347 studies were collected totally, in which 15 articles and 23 trials were selected to study the NS in our meta-analysis. The TNF-alpha test showed moderate accuracy of the diagnosis of NS both in early-onset neonatal sepsis (sensitivity = 0.66, specificity = 0.76, Q* = 0.74) and in late-onset neonatal sepsis (sensitivity = 0.68, specificity = 0.89, Q* = 0.87). We also found the northern hemisphere group in the test has higher sensitivity (0.84) and specificity (0.83). A diagnostic OR analysis found that the study population may be the major reason for the heterogeneity. Accordingly, we suggest that TNF-alpha is also a valuable marker in the diagnosis of NS.
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