Journal
THESCIENTIFICWORLDJOURNAL
Volume 11, Issue -, Pages 2418-2423Publisher
HINDAWI LTD
DOI: 10.1100/2011/429192
Keywords
apoptosis-associated speck-like protein (ASC); caspase-1; inflammasome; nod-like receptors (NLRs); pyroptosis
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Funding
- NHLBI NIH HHS [R01 HL094586, R01 HL094586-02, R01 HL094586-03, R01 HL094586-03S1, R01 HL094586-01A1] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL094586] Funding Source: NIH RePORTER
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The role of apoptosis-associated speck-Like protein (ASC) in the assembly of the inflammasome complex within macrophages has been elucidated in several studies. In this particular role, ASC functions as an adaptor protein by linking nod-like receptors (NLRs) and procaspase-1, thereby leading to the activation of caspase-1 to cleave inflammatory cytokines IL-1 beta and IL-18 and inducing pyroptosis. It has been noted that ASC maintains inflammasome-independent roles, including but not limited to controlling the expression of Dock2 and mitogen-activated protein kinases (MAPK/ERK2) and regulating the NF-kappa B pathway. This paper will emphasize the major roles of ASC during pathogen infection, the mechanisms by which it mediates inflammation, and discuss its more recently discovered functions.
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