Journal
THESCIENTIFICWORLDJOURNAL
Volume 10, Issue -, Pages 1129-1141Publisher
HINDAWI LTD
DOI: 10.1100/tsw.2010.111
Keywords
hippocampus; memory; exercise; cognitive stimulation; rodent
Categories
Funding
- Yale University
- NIH [R01 AG022525, MH065460, AG022525]
- Alzheimer's Association [IIRG-03-6051]
- American Federation for Aging Research/Pfizer
- Claude D. Pepper Older Americans Independence Center at Yale University School of Medicine [P30AG21342]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R03MH065460] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG021342, R01AG022525] Funding Source: NIH RePORTER
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Environmental enrichment has become increasingly utilized in rodent models of aging and neurodegenerative disease in order to prevent or reverse cognitive decline and neuronal dysfunction. However, the potential application of this body of work to human cognitive aging has rarely been discussed. The present article provides an overview of the rodent research that has tested the effects of environmental enrichment on hippocampal and neocortical function, and the types of memories mediated by these brain regions. Although data from models of neurodegenerative disease are presented, primary emphasis is given to studies of aging rodents and to methodological issues (e.g., age, treatment duration, treatment type) central to the mnemonic effectiveness of enrichment treatment. The implications of this work for human cognitive aging are discussed.
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