Journal
THESCIENTIFICWORLDJOURNAL
Volume 8, Issue -, Pages 1250-1253Publisher
HINDAWI LTD
DOI: 10.1100/tsw.2008.152
Keywords
Glypican-1; GPC1; pancreatic cancer; PDAC; angiogenesis; metastasis; tumor growth; microenvironment
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Funding
- NCI NIH HHS [P30 CA062203] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA062203] Funding Source: NIH RePORTER
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The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell-derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.
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