Journal
THERIOGENOLOGY
Volume 80, Issue 6, Pages 557-564Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.theriogenology.2013.06.018
Keywords
Fusarium mycotoxins; Reproductive toxicity; Domestic animals
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On a global scale, cereal grains and animal feed may be contaminated with trichothecenes, such as deoxynivalenol and T-2 toxin, zearalenone (ZEA), and fumonisins, the major mycotoxins of Fusarium fungi. Of these mycotoxins, ZEA is unequivocally implicated in reproductive disorders of swine and other domestic animals. Experiments in vivo and in vitro indicate that ZEA and its metabolites exert estrogenic effects resulting in functional and morphological alterations in reproductive organs. Recently, the potential of trichothecenes and fumonisins to cause reproductive disorders in domestic animals has been investigated. The present review summarizes the toxicological data on the effects of Fusarium mycotoxins on ovarian function, testicular function, placenta and fetus, and puberty/sexual maturity of domestic animals. The results of in vivo animal studies and in vitro tests are reported and discussed. (C) 2013 Elsevier Inc. All rights reserved.
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