Journal
THERIOGENOLOGY
Volume 78, Issue 8, Pages 1749-1762Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.theriogenology.2012.03.031
Keywords
Ungulates; Bovine; Ovine; Stem cells; ESC; iPSC
Categories
Funding
- Australian Postgraduate Award (APA)
- DAIRY FUTURES CRC
- Victorian Government
Ask authors/readers for more resources
Since the successful isolation, characterization and long-term culture of embryonic stem cells (ESCs) from mice in the early 1980s and from humans a decade later, considerable effort has been made to establish ESCs lines from livestock. The derivation of validated ESCs lines is a necessary step if the generation of economically relevant transgenic animals is to be achieved. However, this is still elusive, as the isolation of true ESCs lines for livestock has not been accomplished to date. It has been demonstrated that by forced expression of a defined set of transcription factors, it is possible to reprogram somatic cells to cells that closely resemble an ES-like state. These cells were termed induced pluripotent stem cells (iPSCs). We introduce the basic concepts relating to stem cell biology and give an overview of the various attempts to isolate and generate pluripotent stem cells (PSCs) from species relevant to livestock production. Further, we point out the issues to be addressed and hurdles to be overcome to realize the promise of stem cells in agriculture. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available