Journal
THERAPEUTIC APHERESIS AND DIALYSIS
Volume 15, Issue -, Pages 14-17Publisher
WILEY
DOI: 10.1111/j.1744-9987.2011.00920.x
Keywords
Chronic kidney disease; Cubilin; Diabetic nephropathy; Megalin; Vitamin D deficiency
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Funding
- Ministry of Education, Science, and Culture of Japan [21591023]
- Grants-in-Aid for Scientific Research [21591023] Funding Source: KAKEN
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Vitamin D deficiency is associated with various medical conditions including musculoskeletal disorders, infection, metabolic diseases, and cardiovascular disease. Megalin and cubilin, endocytic receptors in proximal tubule cells, are involved in the reabsorption of vitamin D binding protein from glomerular filtrates and the subsequent intracellular conversion of 25-hydroxyvitamin D-3 to biologically active 1 alpha,25-dihydroxyvitamin D-3. Dysfunction of these receptors, which is commonly found in patients with diabetic nephropathy, even at early stages, may explain why vitamin D deficiency is often complicated in these patients. Therapeutic strategies to protect the functions of these receptors from injury could be used to prevent vitamin D deficiency and its related disorders.
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