Journal
THEORETICAL POPULATION BIOLOGY
Volume 73, Issue 3, Pages 342-348Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.tpb.2008.01.001
Keywords
diffusions; allelic spectrum; Kimura
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It is well known that the neutral allelic frequency spectrum of a population is affected by the history of population size. A number of authors have used this fact to infer history given observed allele frequency data. We ask whether perfect information concerning the spectrum allows precise recovery of the history, and with an explicit example show that the answer is in the negative. This implies some limitations on how informative allelic, spectra can be. (C) 2008 Elsevier Inc. All rights reserved.
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