Journal
THEORETICAL POPULATION BIOLOGY
Volume 74, Issue 4, Pages 291-301Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.tpb.2008.08.003
Keywords
X chromosome; F-ST; Separation of time scales; Coalescent
Funding
- NIGMS NIH HHS [R01 GM081441-02, GM-28016, GM-081441, R01 GM081441, R01 GM028016-27, R01 GM028016] Funding Source: Medline
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Evolutionists have debated whether population-genetic parameters, such as effective population size and migration rate, differ between males and females. in humans, most analyses of this problem have focused on the Y chromosome and the mitochondrial genome, while the X chromosome has largely been omitted from the discussion. Past studies have compared F-ST values for the Y chromosome and mitochondrion under a model with migration rates that differ between the sexes but with equal male and female Population sizes. In this study we investigate rates of coalescence for X-linked and autosomal lineages in an island model with different population sizes and migration rates for males and females, obtaining the mean time to coalescence for pairs of lineages from the same deme and for pairs of lineages from different denies. We apply our results to microsatellite data from the Human Genome Diversity Panel, and we examine the male and female migration rates implied by observed F-ST values. (c) 2008 Elsevier Inc. All rights reserved.
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