Journal
JOURNAL OF DIABETES
Volume 7, Issue 6, Pages 779-790Publisher
WILEY
DOI: 10.1111/1753-0407.12239
Keywords
diabetic cardiomyopathy; echocardiography; left ventricular dysfunction; obesity; type 2 diabetes mellitus
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Funding
- South-Eastern Norway Regional Health Authority
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BackgroundSubclinical left ventricular (LV) dysfunction is prevalent in type 2 diabetes (T2DM). As obesity has been proposed as one causal factor in the disease process, this could bias the reported prevalences. We wanted to characterize echocardiographic LV dysfunction in obese T2DM subjects as compared to non-diabetic obese controls. MethodsOne hundred patients with T2DM without clinical signs of heart failure (29% females, meanSD age 58.410.5 years, body mass index (BMI) 30.15.5kg/m(2), blood pressure (BP) 14118/839mmHg) and 100 non-diabetic controls (29% females) matched for age (58.610.5 years), BMI (29.8 +/- 4.0kg/m(2)) and systolic BP (140 +/- 14mmHg) underwent echocardiography and color tissue Doppler imaging (TDI). Diastolic function was evaluated with conventional Doppler recordings and early (e) and late (a) myocardial velocities. The ratio between early transmitral filling (E) and the corresponding myocardial tissue velocity (e) served as an index of LV filling pressure. ResultsT2DM patients had more concentric hypertrophy with a relative wall thickness of 0.42 +/- 0.07 vs controls 0.38 +/- 0.07, P<0.001. The T2DM group had signs of diastolic dysfunction with lower E/A ratio (0.91 +/- 0.27 vs. 1.12 +/- 0.38, P<0.001), deceleration time (195 +/- 49 vs 242 +/- 72ms, P<0.001), e (5.7 +/- 2.0 vs. 6.6 +/- 1.8cm/s, P=0.001), and a (6.5 +/- 2.0 vs. 7.6 +/- 1.5cm/s, P<0.001) compared to the controls, and higher E/e (13.3 +/- 4.7 vs. 11.1 +/- 3.5, P<0.001). Thus, there were indications of pseudo normalization and increased filling pressure in the T2DM group, whereas the controls had evidence for relaxation abnormalities without elevated filling pressure. ConclusionCompared to a non-diabetic obese group, more advanced subclinical impairment of diastolic function was seen in T2DM.
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