Journal
TETRAHEDRON-ASYMMETRY
Volume 24, Issue 7, Pages 402-408Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2013.02.014
Keywords
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Funding
- National Natural Science Foundation of China [20972195, 21172270, 21202208]
- Guangdong Engineering Research Center of Chiral Drugs
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An organocatalytic cascade Michael/Michael reaction between curcumins and 2-arylidene-1,3-indandiones has been studied. Prolinol, chiral thiourea-tertiary amines, and cinchona alkaloids were evaluated as catalysts. Quinine was identified as the best catalyst for the transformation. Multicyclic spiro-1,3-indandiones were prepared in moderate to excellent yields, diastereoselectivities, and enantioselectivities. (c) 2013 Elsevier Ltd. All rights reserved.
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