Journal
JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS
Volume 13, Issue 3, Pages E201-E209Publisher
WICHTIG PUBL
DOI: 10.5301/jabfm.5000225
Keywords
Implants; PET; Prostheses; Silk fibroin
Funding
- National Natural Science Foundation of China (NSFC) [51003014, 31100682]
- Doctoral Fund of Ministry of Education of China (RFDP) [20100075110001]
- Programme of Introducing Talents of Discipline to Universities (111 project) [B07024]
- Fundamental Research Funds of Central Universities [12D10147]
Ask authors/readers for more resources
Background: In this study, we fabricated prototype bicomponent polyester/silk fibroin small-diameter arterial prostheses using a specially designed narrow ribbon shuttle loom. Methods: The 2-layered flat fabrics were then heatset on a mandrel to form tubes with a round cross section. Results: The woven samples had a wall thickness between 0.23 mm and 0.29 mm and an inner diameter between 3.53 mm and 3.95 mm, depending on the yarn type and the weave structure. Conclusions: The bicomponent polyester/silk fibroin samples had superior bursting strength, circumferential strength and suture retention strength compared with a commercial small-diameter arterial prosthesis made from ePTFE. In addition, these prototype samples had greater suture retention strengths than a dog femoral artery, which indicates that they have adequate biostability for clinical use. While their amount of radial compliance was superior to that of the ePTFE commercial graft control, it did not match that of a natural artery. So there is still a need for future improvement in compliance. All of the woven prototypes had water permeability values between 26 and 180 ml/(cm(2)*min), which confirms that none of these arterial prostheses needs to be preclotted at the time of implantation. The biocompatibility of the woven prototypes was evaluated using porcine endothelial cells and an MTT assay. Their cytocompatibility was found to be superior to the ePTFE commercial control, and the level of cell attachment was observed to increase on these prototypes woven with a higher silk fibroin content.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available