Journal
TETRAHEDRON-ASYMMETRY
Volume 23, Issue 6-7, Pages 457-460Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2012.03.017
Keywords
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Funding
- National Nature Science Foundation of China [21172152]
- National Basic Research Program of China (973 Program) [2010CB833300]
- Sichuan University
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A chiral titanium complex, formed in situ from Ti(Oi-Pr)(4), (S,S)-N,N'-dibenzyl tartramide and water was found to serve as an efficient catalyst for the asymmetric oxidations of 1H-benzimidazolyl pyridinylmethyl sulfides with cumene hydroperoxide (CHP) in the absence of a base. Several proton pump inhibitors (PPIs), such as esomeprazole, lansoprazole, rabeprazole and pantoprazole were obtained in high yield (up to 92%) and excellent enantiomeric excess (up to 96%). (C) 2012 Elsevier Ltd. All rights reserved.
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