Journal
TETRAHEDRON-ASYMMETRY
Volume 23, Issue 5, Pages 333-338Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2012.02.022
Keywords
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Funding
- Natural Science Foundation of China [20972198]
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The enantiopure multi-functional anti Alzheimer's drug, Ladostigil (TV3326), was prepared by using asymmetric transfer hydrogenation (ATH) as a key step catalyzed by Ru-Cs-DPEN in an HCOONa-H2O-surfactant system. Good chemical yields with high enantiomeric excess were obtained and the catalyst could be recycled another five times. (C) 2012 Elsevier Ltd. All rights reserved.
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