Journal
TETRAHEDRON-ASYMMETRY
Volume 22, Issue 6, Pages 708-712Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2011.04.007
Keywords
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Funding
- National Natural Science Foundation of China [21076052, 20972037]
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The catalytic activity of carbohydrate-derived amino alcohols in the enantioselective aldol reaction of ketones with isatin and its derivatives has been examined for the first time. The carbohydrate-derived amino alcohols 5 were found to be efficient organocatalysts for asymmetric aldol reactions. A variety of isatins were used as substrates and the corresponding aldol products were obtained in high yields (up to 99%) and with moderate enantioselectivities (up to 75%). Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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