4.0 Article

Axially chiral N-heterocyclic carbene gold(I) complex catalyzed asymmetric Friedel-Crafts/cyclization reaction of nitrogen-tethered 1,6-enynes with indole derivatives

Journal

TETRAHEDRON-ASYMMETRY
Volume 22, Issue 23, Pages 2029-2038

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2011.12.004

Keywords

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Funding

  1. Shanghai Municipal Committee of Science and Technology [08dj1400100-2]
  2. National Basic Research Program of China (973) [2010CB833302]
  3. Fundamental Research Funds for the Central Universities
  4. National Natural Science Foundation of China [21072206, 20472096, 20902019, 20872162, 20672127, 20821002, 20732008, 20702059]

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A class of axially chiral NHC-Au(I) complexes has been applied to the asymmetric Friedel-Crafts/cyclization reaction of nitrogen-tethered 1,6-enynes 14 with indole derivatives 15, affording the corresponding Friedel-Crafts and intramolecular cyclization products 16 in good yields and with moderate ee values under mild conditions. (C) 2011 Elsevier Ltd. All rights reserved.

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