4.0 Article

Asymmetric Michael reactions of α,α-disubstituted aldehydes with maleimides using a primary amine thiourea organocatalyst

Journal

TETRAHEDRON-ASYMMETRY
Volume 22, Issue 16-17, Pages 1605-1609

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2011.09.006

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Funding

  1. Japan Society for the Promotion of Science [22590007]
  2. Grants-in-Aid for Scientific Research [22590007] Funding Source: KAKEN

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Primary amine thiourea organocatalyst 8 was used to promote Michael additions of bulky alpha,alpha-disubstituted aldehydes, such as isobutyraldehyde with maleimides to afford the corresponding adducts in high to excellent yields and with up to 91% ee. (C) 2011 Elsevier Ltd. All rights reserved.

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