4.0 Article

Asymmetric construction of quaternary stereocenters by direct conjugate addition of oxindoles to enone

Journal

TETRAHEDRON-ASYMMETRY
Volume 21, Issue 20, Pages 2493-2497

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2010.09.016

Keywords

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Funding

  1. NSFC [20932003, 90813012]
  2. National S&T Major Project of China [2009ZX09503-017]

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Chiral cinchona-based primary amine A was found to catalyze the asymmetric direct conjugate addition of prochiral 3-oxindoles with enones to afford 3 3-disubstituted oxindoles in good yields moderate to high diastereoselectivities and excellent enantioselectivities (C) 2010 Elsevier Ltd All rights reserved

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