Journal
TETRAHEDRON-ASYMMETRY
Volume 21, Issue 9-10, Pages 1221-1225Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2010.03.004
Keywords
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Funding
- Japan Society for the Promotion of Science (JSPS)
- Global COE Program (Chemistry Innovation through Cooperation of Science and Engineering)
- University of Tokyo
- MEXT (Japan)
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The first catalytic asymmetric 1,4-addition reactions of azlactones with acrylic esters have been developed. A chiral coordinative calcium catalyst was found to be effective for these reactions, and the desired 1,4-adducts were obtained in good yields and enantioselectivities. The product was converted to the corresponding alpha-alkylated glutamic acid by acid hydrolysis. (C) 2010 Elsevier Ltd. All rights reserved.
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